Benidipine, a Dihydropyridine-Ca2+ Channel Blocker, Increases the Endothelial Differentiation of Endothelial Progenitor Cells In Vitro
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چکیده
منابع مشابه
Heme oxygenase-1 increases endothelial progenitor cells.
OBJECTIVE Induction of heme oxygenase-1 (HO-1) protects against atherosclerotic disease in part by promoting reendothelialization. As endothelial progenitor cells (EPCs) contribute to reendothelialization, we examined the role of HO-1 on bone marrow and circulating EPCs. METHODS AND RESULTS In a rabbit model of aortic balloon injury, pharmacological induction of HO-1 enhanced reendothelializa...
متن کاملEffect of Scurrula atropurpurea on nitric oxide, endothelial damage, and endothelial progenitor cells of DOCA-salt hypertensive rats
Objective(s):To know whether Scurrula atropurpurea is able to modulate total plasma nitrate/nitrite levels, decrease endothelial damage, and increase endothelial progenitor cells (EPCs) in hypertensive rats. Materials and Methods: The rats were divided in 5 groups: control (normotensive) group, Desoxy cortico sterone (DOCA)-salt hypertensive group, and three DOCA-salt hypertensive groups. All 5...
متن کاملEndothelial progenitor cells: mobilization, differentiation, and homing.
Postnatal bone marrow contains a subtype of progenitor cells that have the capacity to migrate to the peripheral circulation and to differentiate into mature endothelial cells. Therefore, these cells have been termed endothelial progenitor cells (EPCs). The isolation of EPCs by adherence culture or magnetic microbeads has been described. In general, EPCs are characterized by the expression of 3...
متن کاملMethod for in vitro differentiation of bone marrow mesenchymal stem cells into endothelial progenitor cells and vascular endothelial cells
Vascular development is a regulated process and is dependent on the participation and differentiation of many cell types including the proliferation and migration of vascular endothelial cells and differentiation of endothelial progenitor cells (EPCs) to mesodermal precursor cells. Thus, reconstitution of this process in vitro necessitates providing ambient conditions for generating and culturi...
متن کاملPhloroglucinol Inhibits the in vitro Differentiation Potential of CD34 Positive Cells into Endothelial Progenitor Cells
Inhibiting the bioactivities of circulating endothelial progenitor cells (EPCs) results in significant inhibition of neovessel formation during tumor angiogenesis. To investigate the potential effect of phloroglucinol as an EPC inhibitor, we performed several in vitro functional assays using CD34(+) cells isolated from human umbilical cord blood (HUCB). Although a high treatment dose of phlorog...
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ژورنال
عنوان ژورنال: Hypertension Research
سال: 2006
ISSN: 0916-9636,1348-4214
DOI: 10.1291/hypres.29.1047